Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 10/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 3/20 | 0.40 |
| ▸ | FABP4 | P15090 | 2/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK3 | P49761 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4009389 | 0.76 | CDC7 (0.44) | TRPA1CDC7FABP4FABP3FABP5 | |
| SCHEMBL4008240 | 0.73 | TRPA1 (0.49) | TRPA1CDC7CLK2GSK3BCDK5 | |
| SCHEMBL4008940 | 0.71 | ITK (0.50) | CLK2DYRK1ACLK3FGFR1CDK2 | |
| SCHEMBL4008930 | 0.65 | SCN9A (0.36) | FGFR1 | |
| Indazole SCHEMBL4583780 | 0.64 | HSP90AA1 (0.76) | MEN1KMT2ACLK2GSK3BCDK5 | |
| SCHEMBL22001065 | 0.64 | FGFR1 (0.61) | MEN1KMT2ACLK2GSK3BCDK5 | |
| SCHEMBL23783032 | 0.62 | TRPA1 (0.59) | TRPA1CLK2GSK3BCDK5DYRK1A | |
| SCHEMBL9818507 | 0.62 | CA2 (0.72) | MEN1KMT2A | |
| SCHEMBL27663175 | 0.62 | TRPA1 (0.68) | TRPA1CDC7CLK2GSK3BCDK5 | |
| Indazole SCHEMBL27577839 | 0.61 | HSP90AA1 (0.70) | TRPA1MEN1KMT2ACLK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7473701-B2 | Substituted indazoles, compositions containing them, method of production and use | AVENTIS PHARMA S.A. (FR) | 2009-01-06 | — | — | US | claimed |