Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 14/20 | 0.48 |
| ▸ | CLK2 | P49760 | 3/20 | 0.42 |
| ▸ | CLK3 | P49761 | 3/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4009386 | 0.86 | ITK (0.56) | ITKCLK2CLK3DYRK1ACHEK1 | |
| SCHEMBL4011766 | 0.83 | ITK (0.54) | ITKCLK2CLK3DYRK1ACHEK1 | |
| SCHEMBL4010514 | 0.80 | ITK (0.56) | ITKCLK2CLK3DYRK1ACHEK1 | |
| SCHEMBL4008237 | 0.74 | ITK (0.53) | ITKFGFR1TRPA1 | |
| SCHEMBL4008240 | 0.74 | TRPA1 (0.49) | CLK2CLK3DYRK1AFGFR1CDK2 | |
| SCHEMBL4008940 | 0.73 | ITK (0.50) | ITKCLK2CLK3DYRK1ACHEK1 | |
| SCHEMBL4003035 | 0.73 | ITK (0.60) | ITK | |
| SCHEMBL4008236 | 0.73 | NR3C1 (0.38) | TRPA1 | |
| SCHEMBL1459731 | 0.70 | ITK (0.53) | ITKCLK2CLK3DYRK1ACHEK1 | |
| SCHEMBL18487449 | 0.69 | ITK (0.68) | ITKCLK2CLK3DYRK1ACHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7473701-B2 | Substituted indazoles, compositions containing them, method of production and use | AVENTIS PHARMA S.A. (FR) | 2009-01-06 | — | — | US | claimed |