Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 5/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4016970 | 0.87 | NR1H3 (0.50) | NR1H2NR1H3PTGDR2RXRAPDE4A | |
| SCHEMBL4011482 | 0.86 | NR1H2 (0.47) | NR1H2NR1H3PTGDR2RXRAMAPK1 | |
| SCHEMBL4011973 | 0.86 | NR1H2 (0.58) | NR1H2NR1H3PTGDR2RXRA | |
| SCHEMBL4299566 | 0.83 | NR1H2 (0.50) | NR1H2NR1H3PTGDR2RXRAGLO1 | |
| SCHEMBL4010387 | 0.83 | NR1H2 (0.48) | NR1H2NR1H3PTGDR2RXRA | |
| SCHEMBL4017675 | 0.82 | NR1H2 (0.50) | NR1H2NR1H3PTGDR2RXRA | |
| SCHEMBL4012970 | 0.82 | NR1H2 (0.52) | NR1H2NR1H3PTGDR2RXRA | |
| SCHEMBL4011406 | 0.82 | CYP4F2 (0.44) | NR1H2NR1H3PTGDR2RXRAPDE4A | |
| SCHEMBL4009472 | 0.82 | NR1H2 (0.58) | NR1H2NR1H3PTGDR2RXRA | |
| SCHEMBL4016946 | 0.82 | HTR1A (0.47) | PTGDR2MAPTKMT2ASMN1; SMN2ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |