Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 5/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | COMT | P21964 | 6/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4012181 | 0.85 | PTGDR2 (0.45) | NR1H2NR1H3PTGDR2COMTPIK3CD | |
| SCHEMBL4010255 | 0.83 | NR1H2 (0.48) | NR1H2NR1H3PTGDR2GLO1RXRA | |
| SCHEMBL4017261 | 0.81 | NR1H2 (0.58) | NR1H2NR1H3PTGDR2GLO1RXRA | |
| SCHEMBL4018184 | 0.81 | PIK3CD (0.54) | NR1H2NR1H3PTGDR2PIK3CDGLO1 | |
| SCHEMBL17044085 | 0.80 | KDR (0.46) | NR1H2NR1H3PTGDR2COMTKDM4E | |
| SCHEMBL4016970 | 0.80 | NR1H3 (0.50) | NR1H2NR1H3PTGDR2GLO1RXRA | |
| SCHEMBL4011973 | 0.79 | NR1H2 (0.58) | NR1H2NR1H3PTGDR2RXRA | |
| SCHEMBL4010284 | 0.79 | NR1H2 (0.53) | NR1H2NR1H3PTGDR2PIK3CDKDM4E | |
| SCHEMBL4011406 | 0.78 | CYP4F2 (0.44) | NR1H2NR1H3PTGDR2RXRACCNT1 | |
| SCHEMBL17044115 | 0.78 | KDM4E (0.44) | NR1H2NR1H3PTGDR2COMTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |