Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.53 |
| ▸ | DRD2 | P14416 | 4/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 4/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL402428 | 0.91 | HTR1A (0.49) | HTR1ADRD2TAAR1FAAHHTT | |
| SCHEMBL5653128 | 0.87 | CCR3 (0.46) | HTR1ADRD2HTTCCR3RORC | |
| SCHEMBL399571 | 0.85 | EPHX2 (0.47) | HTR1ADRD2TAAR1FAAHHTT | |
| SCHEMBL401903 | 0.83 | EPHX2 (0.45) | HTR1ADRD2EPHX2AHRMEN1 | |
| SCHEMBL402492 | 0.82 | RORC (0.49) | HTR1ADRD2TAAR1FAAHHTT | |
| SCHEMBL3199702 | 0.81 | DDX3X (0.43) | HTR1AEPHX2CCR3RORCDHODH | |
| SCHEMBL402102 | 0.81 | AHR (0.49) | HTR1ADRD2TAAR1FAAHHTT | |
| SCHEMBL402505 | 0.80 | RORC (0.47) | HTR1ADRD2TAAR1FAAHHTT | |
| SCHEMBL5136854 | 0.80 | RORC (0.46) | FAAHCCR3AHRRORCDHODH | |
| SCHEMBL3206142 | 0.79 | RORC (0.49) | HTR1ADRD2TAAR1FAAHCCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765327-A4 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS INC (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1765327-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2007-03-28 | — | — | EP | claimed |
| WO-2006009726-A2 | SUBSTITUTED UREA DERIVATIVES FOR TREATING CARDIAC DISEASES | CYTOKINETICS, INC. (US) | 2006-01-26 | — | — | WO | claimed |