Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Thiamphenicol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.86 |
| ▸ | TSHR | P16473 | 2/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.58 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.58 |
| ▸ | RPS17 | P08708 | 1/20 | 0.58 |
| ▸ | RPSA | P08865 | 1/20 | 0.58 |
| ▸ | RPS2 | P15880 | 1/20 | 0.58 |
| ▸ | RPL35A | P18077 | 1/20 | 0.58 |
| ▸ | RPL7 | P18124 | 1/20 | 0.58 |
| ▸ | RPL17 | P18621 | 1/20 | 0.58 |
| ▸ | RPS4Y1 | P22090 | 1/20 | 0.58 |
| ▸ | RPS3 | P23396 | 1/20 | 0.58 |
| ▸ | RPS12 | P25398 | 1/20 | 0.58 |
| ▸ | RPL13 | P26373 | 1/20 | 0.58 |
| ▸ | RPL10 | P27635 | 1/20 | 0.58 |
| ▸ | RPL12 | P30050 | 1/20 | 0.58 |
| ▸ | RPL9; RPL9P7; RPL9P8; RPL9P9 | P32969 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Racephenicol SCHEMBL30388685 | 0.99 | LMNA (0.84) | LMNATSHRCYP3A4MEN1KMT2A | |
| Thiamphenicol SCHEMBL365612 | 0.99 | LMNA (0.84) | LMNATSHRCYP3A4MEN1KMT2A | |
| Racephenicol SCHEMBL30277834 | 0.93 | LMNA (1.00) | LMNATSHRCYP3A4MEN1KMT2A | |
| Racephenicol SCHEMBL8895477 | 0.93 | LMNA (1.00) | LMNATSHRCYP3A4MEN1KMT2A | |
| Thiamphenicol SCHEMBL34635 | 0.93 | LMNA (1.00) | LMNATSHRCYP3A4MEN1KMT2A | |
| Thiamphenicol SCHEMBL10380783 | 0.92 | LMNA (0.88) | LMNATSHRCYP3A4MEN1KMT2A | |
| Thiamphenicol SCHEMBL6245287 | 0.91 | LMNA (0.97) | LMNATSHRCYP3A4MEN1KMT2A | |
| Thiamphenicol SCHEMBL364349 | 0.88 | LMNA (0.67) | LMNATSHRCYP3A4MEN1KMT2A | |
| Florfenicol SCHEMBL3834996 | 0.87 | LMNA (0.90) | LMNATSHRCYP3A4MEN1KMT2A | |
| Thiamphenicol SCHEMBL10911238 | 0.85 | LMNA (0.75) | LMNATSHRCYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116046963-A | Method for detecting thiamphenicol hydrochloride glycine ester enantiomer | 北京四环科宝制药股份有限公司 | 2023-05-02 | — | — | CN | claimed |
| WO-2018112511-A1 | BIOFILM DISRUPTING COMPOSITION | WHITELEY CORPORATION PTY LTD (AU) | 2018-06-28 | — | — | WO | claimed |
| CN-101623499-A | Medical composition of antibiotic and pidotimod as well as preparation method and medical application thereof | XIHONG YANG | 2010-01-13 | — | — | CN | claimed |
| EP-1212049-B1 | USE OF THIAMPHENICOL FOR THETREATMENT OF CHLAMYDIA PNEUMONIAE INFECTIONS | ZAMBON SPA (IT) | 2005-07-06 | — | — | EP | claimed |
| US-6833389-B2 | Thiamphenicol glycinate or salts, thiamphenicol glycinate acetylcysteinate or thiamphenicol glycinate hydrochloride | ZAMBON GROUP S.P.A. (IT) | 2004-12-21 | — | — | US | claimed |
| US-20030100614-A1 | Use of thiamphenicol and derivatives thereof for the preparation of pharmaceutical compositions useful in the treatment of chlamydia pneumoniae infections | ZAMBON S.P.A. (IT) | 2003-05-29 | — | — | US | claimed |
| EP-0088943-B1 | COMPOSITION FOR THE RESORPTION OF INJECTED ANTIBACTERIAL SUBSTANCES AND MIXTURES CONTAINING A BENZYL AMINE DERIVATIVE | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 1986-08-13 | — | — | EP | claimed |
| CN-115452973-B | Method for detecting ethyl chloroformate in thiamphenicol hydrochloride glycine ester | 珠海润都制药股份有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-115452973-B | Method for detecting ethyl chloroformate in thiamphenicol hydrochloride glycine ester | 珠海润都制药股份有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-116046963-A | Method for detecting thiamphenicol hydrochloride glycine ester enantiomer | 北京四环科宝制药股份有限公司 | 2023-05-02 | — | — | CN | disclosed |
| EP-2576778-B1 | TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN RODENTS | UNIV KYOTO (JP) | 2017-08-09 | — | — | EP | disclosed |
| US-9273364-B2 | Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms | KYOTO UNIVERSITY (JP) | 2016-03-01 | — | — | US | disclosed |
| CN-103040722-B | Hydrochloride thiamphenicol glycinate lipidosome injection | HAINAN BAISITE PHARMACEUTICAL TECHNOLOGY CO LTD | 2014-07-02 | — | — | CN | disclosed |
| WO-2004064912-A1 | AN OTORHINOLOGICAL DELIVERY DEVICE | SCHERING OY (FI) | 2004-08-05 | — | — | WO | disclosed |
| US-20030100614-A1 | Use of thiamphenicol and derivatives thereof for the preparation of pharmaceutical compositions useful in the treatment of chlamydia pneumoniae infections | ZAMBON S.P.A. (IT) | 2003-05-29 | — | — | US | disclosed |
| US-20030092689-A1 | Regimen for treating prostate tissue and surgical kit for use in the regimen | BOSTON SCIENTIFIC SCIMED, INC. | 2003-05-15 | — | — | US | disclosed |
| WO-2003005889-A2 | SURGICAL KIT FOR TREATING PROSTATE TISSUE | AMS RESEARCH CORPORATION (US) | 2003-01-23 | — | — | WO | disclosed |
| US-4918108-A | ADMINISTERING OXYTETRACYCLINE WITH DIBROMOBENZYLAMINE DERIVATIVE | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 1990-04-17 | — | — | US | disclosed |
| US-4705803-A | Method of improving resorption of injected antibacterially active substances or combinations | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 1987-11-10 | — | — | US | disclosed |
| US-3823182-A | PROCESS FOR THE PREPARATION OF THIAMPHENICOL GLYCINATE | EISAI CO LTD | 1974-07-09 | — | — | US | disclosed |