Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Thiamphenicol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.88 |
| ▸ | TSHR | P16473 | 2/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.59 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.59 |
| ▸ | RPS17 | P08708 | 1/20 | 0.59 |
| ▸ | RPSA | P08865 | 1/20 | 0.59 |
| ▸ | RPS2 | P15880 | 1/20 | 0.59 |
| ▸ | RPL35A | P18077 | 1/20 | 0.59 |
| ▸ | RPL7 | P18124 | 1/20 | 0.59 |
| ▸ | RPL17 | P18621 | 1/20 | 0.59 |
| ▸ | RPS4Y1 | P22090 | 1/20 | 0.59 |
| ▸ | RPS3 | P23396 | 1/20 | 0.59 |
| ▸ | RPS12 | P25398 | 1/20 | 0.59 |
| ▸ | RPL13 | P26373 | 1/20 | 0.59 |
| ▸ | RPL10 | P27635 | 1/20 | 0.59 |
| ▸ | RPL12 | P30050 | 1/20 | 0.59 |
| ▸ | RPL9; RPL9P7; RPL9P8; RPL9P9 | P32969 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Racephenicol SCHEMBL8895477 | 0.94 | LMNA (1.00) | LMNATSHRCYP3A4MEN1KMT2A | |
| Racephenicol SCHEMBL30277834 | 0.94 | LMNA (1.00) | LMNATSHRCYP3A4MEN1KMT2A | |
| Thiamphenicol SCHEMBL34635 | 0.94 | LMNA (1.00) | LMNATSHRCYP3A4MEN1KMT2A | |
| Thiamphenicol SCHEMBL6245287 | 0.92 | LMNA (0.97) | LMNATSHRCYP3A4MEN1KMT2A | |
| Thiamphenicol SCHEMBL401137 | 0.92 | LMNA (0.86) | LMNATSHRCYP3A4MEN1KMT2A | |
| Racephenicol SCHEMBL30388685 | 0.91 | LMNA (0.84) | LMNATSHRCYP3A4MEN1KMT2A | |
| Thiamphenicol SCHEMBL365612 | 0.91 | LMNA (0.84) | LMNATSHRCYP3A4MEN1KMT2A | |
| Thiamphenicol SCHEMBL10911238 | 0.90 | LMNA (0.75) | LMNATSHRCYP3A4MEN1KMT2A | |
| Florfenicol SCHEMBL3834996 | 0.88 | LMNA (0.90) | LMNATSHRCYP3A4MEN1KMT2A | |
| Florfenicol SCHEMBL4418722 | 0.85 | LMNA (0.84) | LMNATSHRCYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990000614-A1 | RECEPTOR SPECIFIC PROTEINS AND THEIR USE IN RECEPTOR TYPING | BAYLOR COLLEGE OF MEDICINE (US) | 1990-01-25 | — | — | WO | disclosed |
| US-4575506-A | THIAMPHENICOL | ZAMBON S.P.A. (IT) | 1986-03-11 | — | — | US | disclosed |