Thiamphenicol

Thiamphenicol

SCHEMBL34635

CS(=O)(=O)c1ccc([C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 1.00
TSHR P16473 2/20 1.00
CYP3A4 P08684 3/20 0.78
MEN1 O00255 1/20 0.78
KMT2A Q03164 1/20 0.78
RPLP1 P05386 1/20 0.65
RPLP0 P05388 1/20 0.65
RPS17 P08708 1/20 0.65
RPSA P08865 1/20 0.65
RPS2 P15880 1/20 0.65
RPL35A P18077 1/20 0.65
RPL7 P18124 1/20 0.65
RPL17 P18621 1/20 0.65
RPS4Y1 P22090 1/20 0.65
RPS3 P23396 1/20 0.65
RPS12 P25398 1/20 0.65
RPL13 P26373 1/20 0.65
RPL10 P27635 1/20 0.65
RPL12 P30050 1/20 0.65
RPL9; RPL9P7; RPL9P8; RPL9P9 P32969 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Racephenicol SCHEMBL8895477 1.00 LMNA (1.00) LMNATSHRCYP3A4MEN1KMT2A
Racephenicol SCHEMBL30277834 1.00 LMNA (1.00) LMNATSHRCYP3A4MEN1KMT2A
Thiamphenicol SCHEMBL6245287 0.99 LMNA (0.97) LMNATSHRCYP3A4MEN1KMT2A
Florfenicol SCHEMBL3834996 0.94 LMNA (0.90) LMNATSHRCYP3A4MEN1KMT2A
Thiamphenicol SCHEMBL10380783 0.94 LMNA (0.88) LMNATSHRCYP3A4MEN1KMT2A
Thiamphenicol SCHEMBL401137 0.93 LMNA (0.86) LMNATSHRCYP3A4MEN1KMT2A
Racephenicol SCHEMBL30388685 0.92 LMNA (0.84) LMNATSHRCYP3A4MEN1KMT2A
Thiamphenicol SCHEMBL365612 0.92 LMNA (0.84) LMNATSHRCYP3A4MEN1KMT2A
Thiamphenicol SCHEMBL9295760 0.91 RPLP1 (0.83) LMNATSHRCYP3A4MEN1KMT2A
Florfenicol SCHEMBL3637832 0.88 LMNA (1.00) LMNATSHRCYP3A4MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 13560 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 US claimed
US-12576124-B2 Formulation of a conjugate of a tubulysin analog to a cell-binding molecule HANGZHOU DAC BIOTECH CO., LTD (CN) 2026-03-17 US claimed
US-20260027140-A1 COMPOSITIONS AND METHODS FOR TREATING AND AMELIORATING RESPIRATORY CONDITIONS AND INFLAMMATION OF MUCOSA ATOPIC MEDICAL INC (US) 2026-01-29 US claimed
US-12465623-B2 Use of parasites and extracellular vesicles obtained from parasites in cancer treatment YEDITEPE UNIVERSITESI (TR) 2025-11-11 US claimed
US-20250339551-A1 AN ANTIBODY-DRUG CONJUGATE HAVING TWO OR MORE DIFFERENT FUNCTIONAL SMALL MOLECULES FOR ENHANCED TREATMENT OF REFRACTORY DISEASES HANGZHOU SEEHE BIOTECHNOLOGY CO., LTD (CN) 2025-11-06 US claimed
EP-4642492-A1 AN ANTIBODY-DRUG CONJUGATE HAVING TWO OR MORE FUNCTIONAL SMALL MOLECULE COMPOUNDS FOR ENHANCED TREATMENT OF REFRACTORY DISEASES Hangzhou Seehe Biotechnology Co., Ltd (CN) 2025-11-05 EP claimed
EP-4642484-A1 TARGETED TREATMENT OF PROSTATE CANCERS AND OTHER TUMORS BY AN ANTIBODY-DRUG CONJUGATE Hangzhou Seehe Biotechnology Co., Ltd (CN) 2025-11-05 EP claimed
US-20250326778-A1 PYRAZOLE COMPOUNDS AND METHOD FOR MAKING AND USING THE COMPOUNDS RIGEL PHARMACEUTICALS, INC. (US) 2025-10-23 US claimed
EP-3965808-B1 USE OF PARASITES AND EXTRACELLULAR VESICLES OBTAINED FROM PARASITES IN CANCER TREATMENT UNIV YEDITEPE (TR) 2025-09-03 EP claimed
CN-120161197-A Immunodetection method for analogue with accurate quantitative structure and application thereof 华南农业大学 2025-06-17 CN claimed
US-4945181-A Method for resolution of racemic thiamphenicol precursors and intermediates therefor BOEHRINGER MANNHEIM GMBH (DE) 1990-07-31 US claimed
EP-0357661-A1 METHOD FOR THE ESTIMATION OF REDUCED PYRIDINE NUCLEOTIDES AND USE OF THE METHOD FOR ESTIMATION OF CO-A AND ANTIBIOTICS PUBLIC HEALTH LABORATORY SERVICE BOARD (GB) 1990-03-14 EP claimed
EP-0323846-A2 Process of preparing thiamphenicol NIPPON ZEON CO., LTD. (JP) 1989-07-12 EP claimed
EP-0224902-B1 PROCESS FOR THE PREPARATION OF D-THREO-1(P-METHYLSULFONYLPHENYL)-2-DICHLORACETAMIDO-PROPANDIOL-1,3-(THIAMPHENICOL)AND USE OF SUITABLE INTERMEDIATE PRODUCTS Roche Diagnostics GmbH (DE) 1989-04-12 EP claimed
WO-1988008882-A1 METHOD FOR THE ESTIMATION OF REDUCED PYRIDINE NUCLEOTIDES AND USE OF THE METHOD FOR ESTIMATION OF CO-A AND ANTIBIOTICS THE PUBLIC HEALTH LABORATORY SERVICE BOARD (GB) 1988-11-17 WO claimed
EP-0224902-A1 Process for the preparation of D-threo-1(p-methylsulfonylphenyl)-2-dichloracetamido-propandiol-1,3-(Thiamphenicol)and use of suitable intermediate products Roche Diagnostics GmbH (DE) 1987-06-10 EP claimed
EP-0088943-B1 COMPOSITION FOR THE RESORPTION OF INJECTED ANTIBACTERIAL SUBSTANCES AND MIXTURES CONTAINING A BENZYL AMINE DERIVATIVE BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 1986-08-13 EP claimed
US-4575506-A THIAMPHENICOL ZAMBON S.P.A. (IT) 1986-03-11 US claimed
EP-0150790-A2 Process for preparing stabilized polyisocyanates, stabilized isocyanates with delayed reactivity and their use in polyurethane preparation BAYER AG (DE) 1985-08-07 EP claimed
EP-0088943-A2 Composition for the resorption of injected antibacterial substances and mixtures containing a benzyl amine derivative BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 1983-09-21 EP claimed