Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 10/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 9/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.35 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | DRD4 | P21917 | 4/20 | 0.35 |
| ▸ | DRD3 | P35462 | 4/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4016970 | 0.88 | NR1H3 (0.50) | NR1H3NR1H2RXRAPTGDR2PDE4A | |
| SCHEMBL4012080 | 0.88 | NR1H2 (0.47) | NR1H3NR1H2RXRAPTGDR2PDE4A | |
| SCHEMBL4011482 | 0.86 | NR1H2 (0.47) | NR1H3NR1H2RXRAPTGDR2PDE4A | |
| SCHEMBL4013386 | 0.85 | PTGDR2 (0.39) | NR1H3NR1H2RXRAPTGDR2PDE4A | |
| SCHEMBL4011996 | 0.81 | NR1H2 (0.66) | NR1H3NR1H2RXRAPTGDR2 | |
| SCHEMBL4017522 | 0.80 | NR1H2 (0.45) | NR1H3NR1H2RXRAPTGDR2PDE4A | |
| SCHEMBL4018729 | 0.79 | NR1H2 (0.53) | NR1H3NR1H2RXRAPTGDR2 | |
| SCHEMBL4012181 | 0.79 | PTGDR2 (0.45) | NR1H3NR1H2RXRAPTGDR2PDE4D | |
| SCHEMBL4012339 | 0.78 | NR1H2 (0.49) | NR1H3NR1H2RXRAPTGDR2PDE4A | |
| SCHEMBL4012778 | 0.78 | NR1H2 (0.56) | NR1H3NR1H2RXRAPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |