Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MMP14 | P50281 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4009254 | 0.84 | NR1H2 (0.47) | MAPK14PDE4DKDM4ESMN1; SMN2LMNA | |
| SCHEMBL4016936 | 0.84 | HTR1A (0.46) | MAPK14PDE4DKDM4ESMN1; SMN2LMNA | |
| SCHEMBL4020656 | 0.84 | PTGDR2 (0.41) | MAPK14PDE4DKDM4ESMN1; SMN2LMNA | |
| SCHEMBL4016535 | 0.82 | PIK3CD (0.61) | NR4A2PDE4DKDM4ESMN1; SMN2LMNA | |
| SCHEMBL4012181 | 0.82 | PTGDR2 (0.45) | MAPK14PDE4DKDM4ESMN1; SMN2LMNA | |
| SCHEMBL27809134 | 0.81 | NR4A2 (0.51) | NR4A2PDE4DKDM4ESMN1; SMN2LMNA | |
| SCHEMBL4017565 | 0.78 | NR1H2 (0.47) | NR4A2MAPK14PDE4DKDM4ESMN1; SMN2 | |
| SCHEMBL27809136 | 0.78 | NR4A2 (0.51) | NR4A2MAPK14PDE4DKDM4ESMN1; SMN2 | |
| SCHEMBL2451386 | 0.78 | SMN1; SMN2 (0.40) | NR4A2MAPK14PDE4DKDM4ESMN1; SMN2 | |
| SCHEMBL4017818 | 0.77 | NR4A2 (0.54) | NR4A2MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541751-A | Quinoline compounds | WYETH CORP (US) | 2009-09-23 | — | — | CN | disclosed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |