Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 7/20 | 0.53 |
| ▸ | LTA4H | P09960 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL40125 | 1.00 | FKBP1A (0.53) | FKBP1ALTA4HSIGMAR1POLBMEN1 | |
| SCHEMBL40181 | 0.90 | SIGMAR1 (0.54) | FKBP1ASIGMAR1POLB | |
| SCHEMBL40182 | 0.90 | SIGMAR1 (0.54) | FKBP1ASIGMAR1POLB | |
| SCHEMBL15444464 | 0.83 | SIGMAR1 (0.43) | FKBP1ALTA4HSIGMAR1ALDH1A1CYP3A4 | |
| SCHEMBL15432839 | 0.83 | SIGMAR1 (0.43) | FKBP1ALTA4HSIGMAR1ALDH1A1CYP3A4 | |
| SCHEMBL4283767 | 0.77 | HRH3 (0.56) | SIGMAR1ALDH1A1 | |
| SCHEMBL7181767 | 0.77 | MEN1 (0.60) | FKBP1ALTA4HPOLBMEN1KMT2A | |
| SCHEMBL6540812 | 0.77 | MEN1 (0.60) | FKBP1ALTA4HPOLBMEN1KMT2A | |
| SCHEMBL934366 | 0.77 | MMEL1 (0.58) | FKBP1ALTA4HPOLBALDH1A1CYP3A4 | |
| SCHEMBL2707345 | 0.77 | MMEL1 (0.58) | FKBP1ALTA4HPOLBALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| EP-2590656-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |