Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | FKBP1A | P62942 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL40181 | 0.81 | SIGMAR1 (0.54) | SIGMAR1FKBP1ASMN1; SMN2SLC6A1POLB | |
| SCHEMBL40182 | 0.81 | SIGMAR1 (0.54) | SIGMAR1FKBP1ASMN1; SMN2SLC6A1POLB | |
| SCHEMBL10660541 | 0.77 | ACE (0.54) | SMN1; SMN2PREP | |
| SCHEMBL5732641 | 0.76 | ACE (0.47) | SMN1; SMN2PREP | |
| SCHEMBL22798190 | 0.76 | ACE (0.53) | SIGMAR1SMN1; SMN2PREP | |
| SCHEMBL18619556 | 0.76 | ACE (0.53) | SIGMAR1SMN1; SMN2PREP | |
| SCHEMBL18734805 | 0.76 | SMN1; SMN2 (0.51) | SIGMAR1FKBP1ASMN1; SMN2SLC6A1POLB | |
| SCHEMBL19880370 | 0.76 | SMN1; SMN2 (0.51) | SIGMAR1FKBP1ASMN1; SMN2SLC6A1POLB | |
| SCHEMBL19880369 | 0.76 | SMN1; SMN2 (0.51) | SIGMAR1FKBP1ASMN1; SMN2SLC6A1POLB | |
| SCHEMBL2188473 | 0.75 | CTSK (0.49) | SIGMAR1SMN1; SMN2CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| EP-2590656-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |