Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GGT1 | P19440 | 1/20 | 0.44 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5732584 | 0.84 | POLB (0.45) | CYP1A2PREP | |
| SCHEMBL10071095 | 0.78 | ACE (0.52) | ACESMN1; SMN2SPHK1 | |
| SCHEMBL1666132 | 0.78 | SLC6A1 (0.51) | ACESMN1; SMN2SPHK1CYP1A2 | |
| SCHEMBL9436228 | 0.78 | ACE (0.67) | ACE | |
| SCHEMBL21340465 | 0.78 | FKBP1A (0.55) | PREP | |
| SCHEMBL5732638 | 0.78 | ACE (0.67) | ACE | |
| SCHEMBL5733034 | 0.78 | ACE (0.67) | ACE | |
| SCHEMBL5733042 | 0.77 | FKBP1A (0.54) | PREP | |
| SCHEMBL9436236 | 0.77 | FKBP1A (0.54) | PREP | |
| SCHEMBL21241445 | 0.76 | ACE (0.45) | ACESMN1; SMN2SPHK1PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973518-B1 | SEMI-SYNTHETIC STUDIES TOWARD DIDEMNIN ANALOGUES | UNIV ILLINOIS (US) | 2006-03-29 | — | — | EP | disclosed |
| US-6841530-B2 | Semi-synthetic studies toward didemnin analogues | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2005-01-11 | — | — | US | disclosed |
| EP-0973518-A4 | SEMI-SYNTHETIC STUDIES TOWARD DIDEMNIN ANALOGUES | UNIV ILLINOIS (US) | 2004-05-26 | — | — | EP | disclosed |
| US-20020037835-A1 | Semi-synthetic studies toward didemnin analogues | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, THE | 2002-03-28 | — | — | US | disclosed |
| US-20010007855-A1 | SEMI-SYNTHETIC STUDIES TOWARD DIDEMNIN ANALOGUES | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, THE | 2001-07-12 | — | — | US | disclosed |
| EP-0973518-A1 | SEMI-SYNTHETIC STUDIES TOWARD DIDEMNIN ANALOGUES | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998017275-A1 | SEMI-SYNTHETIC STUDIES TOWARD DIDEMNIN ANALOGUES | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 1998-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010007855-A1 | SEMI-SYNTHETIC STUDIES TOWARD DIDEMNIN ANALOGUES | FAR1, FASN, GOT1 | ACE 561/4885SMN1; SMN2 1702/4885GGT1 2066/4885 |
| US-20020037835-A1 | Semi-synthetic studies toward didemnin analogues | FAR1, FASN, GOT1 | ACE 561/4885SMN1; SMN2 1702/4885GGT1 2066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.