Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.42 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.41 |
| ▸ | GPR142 | Q7Z601 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | LIPE | Q05469 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4521074 | 0.79 | RAB9A (0.52) | RYR2SMN1; SMN2FAAHMAPTALDH1A1 | |
| SCHEMBL30730257 | 0.77 | CTNNB1 (0.47) | SMN1; SMN2ALDH1A1GAAGFER | |
| SCHEMBL19926744 | 0.75 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTHTTALDH1A1GAA | |
| SCHEMBL3789225 | 0.74 | RIPK1 (0.46) | RIPK1CREBBPGPR142MAPTHTT | |
| SCHEMBL16004253 | 0.73 | SMN1; SMN2 (0.54) | RIPK1CREBBPRYR2GPR142SMN1; SMN2 | |
| SCHEMBL31409466 | 0.72 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTHTTALDH1A1GAA | |
| SCHEMBL3715690 | 0.72 | RIPK1 (0.44) | RIPK1CREBBPGPR142ALDH1A1PIK3CA | |
| SCHEMBL26087589 | 0.71 | CHRM2 (0.48) | SMN1; SMN2LIPEMAPTALDH1A1GAA | |
| SCHEMBL16004138 | 0.71 | SIGMAR1 (0.48) | GPR142FAAHMAPT | |
| SCHEMBL22993336 | 0.71 | RIPK1 (0.49) | RIPK1CREBBPSMN1; SMN2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |