Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 5/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4012820 | 0.76 | IMPDH2 (0.42) | LMNAPKMMAP4K4IMPDH2IMPDH1 | |
| SCHEMBL7147816 | 0.75 | ADORA2A (0.52) | LMNAPKM | |
| SCHEMBL30463597 | 0.70 | PTK2 (0.52) | LMNAPKMMAP4K4IMPDH2IMPDH1 | |
| SCHEMBL10936938 | 0.68 | ADORA1 (0.58) | LMNAMAP3K14GRM4 | |
| SCHEMBL24310606 | 0.67 | FGFR1 (0.50) | MAP3K14NUDT1GRM4 | |
| SCHEMBL3433303 | 0.67 | HSP90AA1 (0.49) | MAP4K4PTK2GRM4NOTUMGAA | |
| SCHEMBL23494350 | 0.67 | HTT (0.41) | MAP3K14NUDT1PTK2GRM4 | |
| SCHEMBL29430426 | 0.66 | DHFR (0.49) | LMNAPKMMAP4K4PTK2CYP11B1 | |
| SCHEMBL4471892 | 0.66 | DHFR (0.49) | LMNAPKMMAP4K4PTK2CYP11B1 | |
| SCHEMBL21121007 | 0.66 | KMT2A (0.47) | MAP3K14GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044063-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008001070-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | WO | disclosed |