Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 4/20 | 0.42 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4012818 | 0.76 | LMNA (0.41) | IMPDH2IMPDH1LMNAPKMMAP4K4 | |
| SCHEMBL29430426 | 0.72 | DHFR (0.49) | LMNAPKMMAP4K4PTK2CYP11B1 | |
| SCHEMBL4471892 | 0.72 | DHFR (0.49) | LMNAPKMMAP4K4PTK2CYP11B1 | |
| SCHEMBL4018186 | 0.71 | KDM4E (0.42) | PIK3R1PIK3CAMTOR | |
| SCHEMBL30463597 | 0.70 | PTK2 (0.52) | IMPDH2IMPDH1LMNAPKMMAP4K4 | |
| SCHEMBL4492804 | 0.68 | MAP4K4 (0.57) | MAP4K4PTK2ATRCYP11B1CYP11B2 | |
| SCHEMBL29430393 | 0.68 | MAP4K4 (0.57) | MAP4K4PTK2ATRCYP11B1CYP11B2 | |
| SCHEMBL10917626 | 0.68 | ADORA1 (0.58) | PIK3R1PIK3CAMTORACHERXFP1 | |
| SCHEMBL23494352 | 0.67 | HTT (0.41) | PIK3R1PIK3CAMTORACHEPTK2 | |
| SCHEMBL1806540 | 0.67 | IMPDH2 (0.46) | IMPDH2IMPDH1MTORLMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044063-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008001070-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | WO | disclosed |