Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CASP2 | P42575 | 1/20 | 0.33 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.31 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4014357 | 0.82 | CSNK1E (0.42) | LMNAMAPTTDP1L3MBTL1MEN1 | |
| SCHEMBL4012474 | 0.76 | HDAC3 (0.39) | LMNAMEN1KMT2A | |
| SCHEMBL4016943 | 0.72 | DYRK1A (0.49) | NOX1LMNAMAPTMAPK1TDP1 | |
| SCHEMBL4154294 | 0.72 | DYRK1A (0.49) | NOX1LMNAMAPTMAPK1TDP1 | |
| SCHEMBL19657873 | 0.68 | MAPT (0.60) | NOX1LMNAMAPTMAPK1TDP1 | |
| SCHEMBL1984394 | 0.68 | NOX1 (0.70) | NOX1LMNAMAPTMAPK1TDP1 | |
| SCHEMBL9395281 | 0.67 | MAOA (0.68) | NOX1LMNAMAPTMAPK1TDP1 | |
| SCHEMBL4708265 | 0.67 | MAOA (0.42) | NOX1LMNAMAPTMAPK1TDP1 | |
| SCHEMBL15274808 | 0.64 | MAPT (0.52) | NOX1LMNAMAPTMAPK1TDP1 | |
| SCHEMBL2170658 | 0.64 | DYRK1A (0.61) | LMNAMAPTL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009085226-A2 | INHIBITORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |