Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | NOX1 | Q9Y5S8 | 6/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705856 | 0.89 | NOX1 (0.47) | MAOANOX1L3MBTL1MEN1ADRA2A | |
| SCHEMBL4708643 | 0.87 | MAOA (0.43) | MAOANOX1L3MBTL1MEN1ADRA2A | |
| SCHEMBL9395281 | 0.82 | MAOA (0.68) | MAOANOX1L3MBTL1MEN1ADRA2A | |
| SCHEMBL2495874 | 0.79 | NOX1 (0.52) | MAOANOX1L3MBTL1MEN1ADRA2A | |
| Bromide SCHEMBL2586940 | 0.77 | NOX1 (0.51) | MAOANOX1L3MBTL1MEN1ADRA2A | |
| SCHEMBL28640004 | 0.77 | NOX1 (0.43) | MAOANOX1L3MBTL1MEN1ADRA2A | |
| SCHEMBL19657873 | 0.76 | MAPT (0.60) | MAOANOX1L3MBTL1MEN1ADRA2A | |
| SCHEMBL1984394 | 0.72 | NOX1 (0.70) | NOX1L3MBTL1MEN1ADRA2AADRA2B | |
| SCHEMBL9507748 | 0.72 | MAPK1 (0.40) | L3MBTL1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL18018993 | 0.70 | NOX1 (0.46) | MAOANOX1L3MBTL1MEN1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765797-A4 | PHENOTHIAZINE DERIVATIVES AND THEIR METHOD OF USE | UNIV KANSAS CT FOR RES INC (US) | 2008-02-06 | — | — | EP | disclosed |
| EP-1765797-A1 | PHENOTHIAZINE DERIVATIVES AND THEIR METHOD OF USE | University of Kansas Center for Research, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006002441-A1 | PHENOTHIAZINE DERIVATIVES AND THEIR METHOD OF USE | UNIVERSITY OF KANSAS (US) | 2006-01-05 | — | — | WO | disclosed |
| US-20050288279-A1 | Phenothiazine derivatives and their method of use | KANSAS MEDICAL CENTER, UNIVERSITY OF | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288279-A1 | Phenothiazine derivatives and their method of use | SHBG, GPR119, BRDT | MAOA 1651/4885NOX1 3177/4885L3MBTL1 4480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.