Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 4/20 | 0.51 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4015330 | 0.88 | NR4A2 (0.48) | NR4A2CRHR1TP53SMN1; SMN2PDE2A | |
| SCHEMBL4012142 | 0.86 | ENPP1 (0.44) | NR4A2CRHR1HSP90AA1HSP90AB1TP53 | |
| SCHEMBL4017818 | 0.81 | NR4A2 (0.54) | NR4A2CRHR1PDE2APDE10AGAA | |
| SCHEMBL4017565 | 0.80 | NR1H2 (0.47) | NR4A2HSP90AA1HSP90AB1SMN1; SMN2MEN1 | |
| SCHEMBL4017788 | 0.79 | NR1H2 (0.59) | NR4A2 | |
| SCHEMBL4012832 | 0.78 | NR1H2 (0.57) | NR4A2 | |
| SCHEMBL4012480 | 0.77 | NR1H2 (0.58) | NR4A2 | |
| SCHEMBL4011445 | 0.75 | NR1H2 (0.59) | NR4A2 | |
| SCHEMBL4012195 | 0.75 | NR1H2 (0.45) | NR4A2MEN1KMT2ABDKRB2 | |
| SCHEMBL4016587 | 0.74 | NR1H2 (0.49) | NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |