Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 4/20 | 0.48 |
| ▸ | CRHR1 | P34998 | 6/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4013124 | 0.88 | NR4A2 (0.51) | NR4A2CRHR1SLC2A1PDE2APDE10A | |
| SCHEMBL4015511 | 0.84 | ENPP1 (0.40) | CRHR1SLC2A1ENPP3ENPP1PDE2A | |
| SCHEMBL4019153 | 0.82 | NR4A2 (0.50) | NR4A2CRHR1 | |
| SCHEMBL4013824 | 0.81 | NR1H2 (0.56) | — | |
| SCHEMBL4015309 | 0.78 | NR1H2 (0.53) | NR4A2 | |
| SCHEMBL4012431 | 0.78 | NR1H2 (0.56) | NR4A2 | |
| SCHEMBL4012142 | 0.78 | ENPP1 (0.44) | NR4A2CRHR1SLC2A1ENPP3ENPP1 | |
| SCHEMBL4014463 | 0.77 | NR1H2 (0.43) | — | |
| SCHEMBL4013631 | 0.77 | NR1H2 (0.46) | NR4A2 | |
| SCHEMBL2446897 | 0.75 | FGFR2 (0.41) | PTGESENPP3ENPP1PDE10ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |