Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 3/20 | 0.44 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 2/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4015511 | 0.87 | ENPP1 (0.40) | ENPP1ENPP3TP53CRHR1PDE2A | |
| SCHEMBL4013124 | 0.86 | NR4A2 (0.51) | TP53SMN1; SMN2CRHR1PDE2APDE10A | |
| SCHEMBL4010841 | 0.85 | RORC (0.40) | RORC | |
| SCHEMBL4012143 | 0.83 | ESR1 (0.40) | CRHR1TRPV1PDE2APDE10AGAA | |
| SCHEMBL3509022 | 0.82 | ENPP1 (0.43) | ENPP1ENPP3CRHR1TRPV1PDE2A | |
| SCHEMBL4013857 | 0.82 | NR1H2 (0.47) | ENPP1ENPP3TRPV1TSHRLMNA | |
| SCHEMBL4012184 | 0.81 | NR1H2 (0.46) | SMN1; SMN2TSHRHTTRAB9A | |
| SCHEMBL4017110 | 0.81 | NR1H2 (0.57) | — | |
| SCHEMBL4019268 | 0.79 | NR1H2 (0.59) | — | |
| SCHEMBL4018710 | 0.78 | NR1H2 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |