Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.65 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | TOP2A | P11388 | 2/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | MPI | P34949 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4016535 | 0.82 | PIK3CD (0.61) | PIK3CDCDC7TOP2ANR1H2NR1H3 | |
| SCHEMBL4011409 | 0.82 | PIK3CD (0.61) | PIK3CDCDC7TOP2ANR1H2NR1H3 | |
| SCHEMBL6558762 | 0.81 | PIK3CD (0.60) | PIK3CDCDC7TOP2AHSD17B1HSD17B2 | |
| SCHEMBL1125582 | 0.81 | NR1H2 (0.62) | PIK3CDCDC7TOP2ANR1H2NR1H3 | |
| SCHEMBL4013567 | 0.78 | PIK3CD (0.57) | PIK3CDCDC7TOP2AHSD17B1HSD17B2 | |
| SCHEMBL4016601 | 0.78 | PIK3CD (0.57) | PIK3CDCDC7TOP2ANR1H2NR1H3 | |
| SCHEMBL4017563 | 0.76 | PIK3CD (0.54) | PIK3CDCDC7HSD17B1HSD17B2CCNB2 | |
| SCHEMBL4018184 | 0.76 | PIK3CD (0.54) | PIK3CDCDC7TOP2ANR1H2NR1H3 | |
| SCHEMBL25521412 | 0.76 | PIK3CD (0.42) | PIK3CDTOP2ANR1H2NR1H3KDM4E | |
| SCHEMBL27765105 | 0.75 | PIK3CD (0.53) | PIK3CDCDC7TOP2ANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |