Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 5/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | ACACA | Q13085 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4011409 | 0.81 | PIK3CD (0.61) | PIK3CDHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL4016936 | 0.80 | HTR1A (0.46) | PIK3CDHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL4013847 | 0.80 | MAPK14 (0.46) | PIK3CDFYNHTR1AADRA1DADRA1A | |
| SCHEMBL30275434 | 0.80 | HTR1A (0.54) | HTR1AADRA1DADRA1AADRA1BPTGDR2 | |
| SCHEMBL25289806 | 0.80 | HTR1A (0.54) | HTR1AADRA1DADRA1AADRA1BPTGDR2 | |
| SCHEMBL4013369 | 0.78 | PIK3CD (0.65) | PIK3CDFYNPTGDR2CDC7HSD17B1 | |
| SCHEMBL4016535 | 0.78 | PIK3CD (0.61) | PIK3CDHTR1APTGDR2CDC7HSD17B1 | |
| SCHEMBL6558762 | 0.78 | PIK3CD (0.60) | PIK3CDCDC7ACVR1HSD17B1HSD17B2 | |
| SCHEMBL1125582 | 0.78 | NR1H2 (0.62) | PIK3CDPTGDR2CDC7HSD17B1HSD17B2 | |
| SCHEMBL4013993 | 0.77 | NR1H2 (0.68) | HTR1AADRA1DADRA1AADRA1BACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541751-A | Quinoline compounds | WYETH CORP (US) | 2009-09-23 | — | — | CN | disclosed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |