Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.54 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19991864 | 0.83 | PIK3CA (0.59) | ACVR1NPC1RAB9AAURKATTK | |
| SCHEMBL30583075 | 0.83 | PIK3CA (0.59) | ACVR1NPC1RAB9AAURKATTK | |
| SCHEMBL27433308 | 0.82 | ACVR1 (0.52) | ACVR1TLR8NPC1ESR1TP53 | |
| SCHEMBL27278122 | 0.81 | BMP4 (0.57) | ACVR1TLR8NPC1ESR1TP53 | |
| SCHEMBL28659657 | 0.80 | GRM4 (0.61) | ACVR1CDC7MAPTRAB9AAURKA | |
| SCHEMBL14320615 | 0.80 | AURKA (0.54) | ACVR1FYNNPC1RAB9AAURKA | |
| SCHEMBL21982345 | 0.80 | ACVR1 (0.52) | ACVR1NPC1MAPTRAB9AAURKA | |
| SCHEMBL28647085 | 0.80 | NUDT1 (0.57) | ACVR1TLR8AURKATTKAURKB | |
| SCHEMBL35327 | 0.80 | TGFBR1 (0.60) | ACVR1NPC1ESR1TP53MAPT | |
| SCHEMBL30439957 | 0.80 | TGFBR1 (0.60) | ACVR1NPC1ESR1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541751-A | Quinoline compounds | WYETH CORP (US) | 2009-09-23 | — | — | CN | disclosed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |