Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.57 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.56 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4020656 | 0.80 | PTGDR2 (0.41) | PIK3CDLRRK2PTGDR2ARGSK3B | |
| SCHEMBL4011409 | 0.78 | PIK3CD (0.61) | PIK3CDLRRK2CDC7PTGDR2DYRK1A | |
| SCHEMBL4016535 | 0.78 | PIK3CD (0.61) | PIK3CDLRRK2CDC7PTGDR2NUDT1 | |
| SCHEMBL4013369 | 0.78 | PIK3CD (0.65) | PIK3CDLRRK2CDC7PTGDR2TOP2A | |
| SCHEMBL6558762 | 0.78 | PIK3CD (0.60) | PIK3CDLRRK2CDC7DYRK1ATOP2A | |
| SCHEMBL4012471 | 0.76 | KDM4E (0.42) | LRRK2PTGDR2ARGSK3BDYRK1A | |
| SCHEMBL4013567 | 0.75 | PIK3CD (0.57) | PIK3CDCDC7PTGDR2DYRK1ATOP2A | |
| SCHEMBL1125582 | 0.75 | NR1H2 (0.62) | PIK3CDCDC7PTGDR2ARGSK3B | |
| SCHEMBL1028218 | 0.74 | ESR2 (0.65) | LRRK2ARHSD17B1HSD17B2ADORA2A | |
| SCHEMBL23832886 | 0.73 | HTT (0.46) | LRRK2PTGDR2ARGSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541751-A | Quinoline compounds | WYETH CORP (US) | 2009-09-23 | — | — | CN | disclosed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |