Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 3/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017971 | 0.92 | RAB9A (0.46) | ALDH1A1RAB9ACCR3OPRM1OPRK1 | |
| SCHEMBL3565136 | 0.90 | ALDH1A1 (0.51) | ALDH1A1MEN1POLBKMT2ANAMPT | |
| SCHEMBL4016844 | 0.83 | MAPT (0.45) | PKMCCR3KMT2AMAPT | |
| SCHEMBL3557299 | 0.82 | CCR3 (0.67) | RAB9ACCR3MEN1POLBKMT2A | |
| SCHEMBL3565549 | 0.81 | HTR2A (0.49) | L3MBTL1MEN1POLBKMT2ANAMPT | |
| SCHEMBL3565154 | 0.81 | UTS2R (0.46) | ALDH1A1RAB9ACCR3MEN1POLB | |
| SCHEMBL3564763 | 0.81 | NAMPT (0.47) | RAB9ACCR3MEN1POLBKMT2A | |
| SCHEMBL3557010 | 0.80 | CARM1 (0.52) | ALDH1A1RAB9AMEN1POLBKMT2A | |
| SCHEMBL3559283 | 0.77 | RAB9A (0.44) | RAB9ACCR3MEN1POLBKMT2A | |
| SCHEMBL301872 | 0.77 | NAMPT (0.47) | PKMCCR3MEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670470-B1 | PYRIDINE DERIVATIVES AND USE THEREOF AS UROTENSIN II ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-04-08 | — | — | EP | disclosed |