Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | FBP1 | P09467 | 2/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017971 | 0.91 | RAB9A (0.46) | MAPTKMT2ACCR3 | |
| SCHEMBL4013470 | 0.83 | ALDH1A1 (0.54) | MAPTKMT2APKMCCR3 | |
| SCHEMBL301931 | 0.82 | CACNA1H (0.40) | MAPTHTR1ADRD2HTR6CCR3 | |
| SCHEMBL3564316 | 0.82 | HTR2A (0.55) | MAPTKMT2APKMLMNATP53 | |
| SCHEMBL3562875 | 0.82 | MAPT (0.46) | MAPTKMT2APKMLMNACCR3 | |
| SCHEMBL3561218 | 0.82 | MAPT (0.45) | MAPTKMT2APKMLMNACCR3 | |
| SCHEMBL3565136 | 0.77 | ALDH1A1 (0.51) | MAPTKMT2ALMNAHTR6TP53 | |
| SCHEMBL3557299 | 0.74 | CCR3 (0.67) | KMT2ACCR3 | |
| SCHEMBL6196441 | 0.74 | UTS2R (0.58) | LMNAHTR1ADRD2HTR7HTR6 | |
| SCHEMBL3554924 | 0.74 | L3MBTL1 (0.51) | MAPTLMNATP53MAPK1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670470-B1 | PYRIDINE DERIVATIVES AND USE THEREOF AS UROTENSIN II ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-04-08 | — | — | EP | disclosed |