Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.38 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4014022 | 0.92 | ROCK1 (0.46) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL3223391 | 0.76 | MAPT (0.76) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL4428333 | 0.73 | PTGES (0.43) | MEN1KMT2AMAPTRAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL2177469 | 0.69 | ROCK1 (0.68) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL4013569 | 0.68 | PIN1 (0.52) | MEN1KMT2AMAPTPLK1PIN1 | |
| SCHEMBL22860666 | 0.68 | GUCY1B2 (0.77) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL29495111 | 0.68 | GUCY1B2 (0.77) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL17199295 | 0.67 | MEN1 (0.60) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL18169192 | 0.66 | RAB9A (1.00) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL100896 | 0.66 | MEN1 (0.52) | MEN1KMT2AMAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222262-B2 | Indazolyl derivatives useful as potassium channel modulating agents | NEUROSEARCH A/S (DK) | 2012-07-17 | — | — | US | claimed |
| US-20090325989-A1 | INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2009-12-31 | — | — | US | claimed |
| CN-101516873-A | Indazolyl derivatives useful as potassium channel modulating agents | NEUROSEARCH AS (DK) | 2009-08-26 | — | — | CN | claimed |
| EP-2074113-A1 | INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | NeuroSearch A/S (DK) | 2009-07-01 | — | — | EP | claimed |
| WO-2008040753-A1 | INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2008-04-10 | — | — | WO | claimed |
| US-8222262-B2 | Indazolyl derivatives useful as potassium channel modulating agents | NEUROSEARCH A/S (DK) | 2012-07-17 | — | — | US | disclosed |
| US-8222262-B2 | Indazolyl derivatives useful as potassium channel modulating agents | NEUROSEARCH A/S (DK) | 2012-07-17 | — | — | US | disclosed |
| US-8222262-B2 | Indazolyl derivatives useful as potassium channel modulating agents | NEUROSEARCH A/S (DK) | 2012-07-17 | — | — | US | disclosed |
| US-20090325989-A1 | INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2009-12-31 | — | — | US | disclosed |
| US-20090325989-A1 | INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2009-12-31 | — | — | US | disclosed |
| US-20090325989-A1 | INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2009-12-31 | — | — | US | disclosed |
| CN-101516873-A | Indazolyl derivatives useful as potassium channel modulating agents | NEUROSEARCH AS (DK) | 2009-08-26 | — | — | CN | disclosed |
| EP-2074113-A1 | INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | NeuroSearch A/S (DK) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008040753-A1 | INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2008-04-10 | — | — | WO | disclosed |
| WO-2008040753-A1 | INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2008-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325989-A1 | INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | KCND2, KCNN3, KCNJ2 | MEN1 3022/4885KMT2A 1923/4885MAPT 499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.