Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.65 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.65 |
| ▸ | RELA | Q04206 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA4 | P22748 | 2/20 | 0.51 |
| ▸ | CA7 | P43166 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4117285 | 0.85 | SMN1; SMN2 (0.70) | EPHX2SMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL2719450 | 0.82 | EPHX2 (1.00) | EPHX2SMN1; SMN2HTT | |
| SCHEMBL6332386 | 0.80 | RAB9A (1.00) | EPHX2SMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL4009841 | 0.79 | EPHX2 (0.80) | EPHX2SMN1; SMN2MAPT | |
| SCHEMBL1911236 | 0.78 | SMN1; SMN2 (0.66) | EPHX2SMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL4012357 | 0.74 | EPHX2 (0.59) | EPHX2NPC1POLBMEN1KMT2A | |
| SCHEMBL360174 | 0.74 | SMN1; SMN2 (0.63) | EPHX2SMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL357608 | 0.74 | SMN1; SMN2 (0.63) | EPHX2SMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL4015336 | 0.74 | EPHX2 (0.80) | EPHX2 | |
| SCHEMBL4193206 | 0.73 | EPHX2 (0.80) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009086426-A2 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION | ARETE THERAPEUTICS, INC. (US) | 2009-07-09 | — | — | WO | claimed |
| WO-2009086426-A2 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION | ARETE THERAPEUTICS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |