Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4019861 | 0.79 | KDM4E (0.64) | KDM4EHSD17B10ALDH1A1KMT2AHPGD | |
| SCHEMBL4016302 | 0.76 | KDM4E (0.59) | KDM4EHSD17B10KMT2A | |
| SCHEMBL31483205 | 0.62 | RAB9A (0.42) | KDM4EHSD17B10RAB9AALDH1A1KMT2A | |
| SCHEMBL8480288 | 0.62 | ALDH1A1 (0.70) | RAB9AALDH1A1KMT2AHPGDTSHR | |
| SCHEMBL4014392 | 0.60 | TNKS2 (0.44) | KDM4EHSD17B10KMT2AGRM5 | |
| SCHEMBL27259598 | 0.59 | ALDH1A1 (0.50) | RAB9AALDH1A1KMT2AHPGDTSHR | |
| SCHEMBL25823361 | 0.59 | KDM4E (0.41) | KDM4EHSD17B10KMT2ARXFP1CYP1A2 | |
| SCHEMBL2075661 | 0.58 | KDM4E (0.43) | KDM4EHSD17B10ALDH1A1KMT2ANPSR1 | |
| SCHEMBL11997548 | 0.58 | RAB9A (0.50) | RAB9AALDH1A1KMT2AHPGDTSHR | |
| SCHEMBL16907286 | 0.57 | RXFP1 (0.46) | HSD17B10RAB9AALDH1A1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009087220-A1 | USE OF THIAZOLOIMIDAZOLES, THIAZOLOTETRAZOLES AND THIAZOLOTRIAZOLES AS MGLUR5 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | WO | disclosed |
| WO-2009087220-A1 | USE OF THIAZOLOIMIDAZOLES, THIAZOLOTETRAZOLES AND THIAZOLOTRIAZOLES AS MGLUR5 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | WO | disclosed |