Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.43 |
| ▸ | MAOB | P27338 | 6/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27823231 | 0.89 | PARP10 (0.40) | PARP10PARP15MAOBF10PARP2 | |
| SCHEMBL983929 | 0.87 | PARP10 (0.53) | PARP10PARP15PARP2ACACBFFAR1 | |
| SCHEMBL3325497 | 0.85 | GPR119 (0.52) | — | |
| SCHEMBL4014417 | 0.79 | PDE4A (0.44) | MAOBMAOA | |
| SCHEMBL30384182 | 0.79 | PDE4A (0.44) | MAOBMAOA | |
| SCHEMBL12813515 | 0.76 | SIGMAR1 (0.43) | — | |
| SCHEMBL1390989 | 0.76 | PARP10 (0.53) | PARP10PARP15PARP2FFAR1 | |
| SCHEMBL15537877 | 0.75 | GPR119 (0.58) | — | |
| SCHEMBL7963745 | 0.75 | ALDH1A1 (0.53) | — | |
| SCHEMBL7963747 | 0.75 | ALDH1A1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074103-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008133955-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | EXELIXIS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |