Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 4/20 | 0.50 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.42 |
| ▸ | CD38 | P28907 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | BDKRB2 | P30411 | 3/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017818 | 0.88 | NR4A2 (0.54) | NR4A2CRHR1MAPTGAABDKRB2 | |
| SCHEMBL4012780 | 0.83 | CD38 (0.41) | CD38MAPTGAAL3MBTL1CYP3A4 | |
| SCHEMBL4015330 | 0.82 | NR4A2 (0.48) | NR4A2CRHR1 | |
| SCHEMBL4013817 | 0.80 | NR4A2 (0.54) | NR4A2CRHR1MAPTGAABDKRB2 | |
| SCHEMBL4012143 | 0.77 | ESR1 (0.40) | NR4A2CRHR1CD38MAPTGAA | |
| SCHEMBL1026984 | 0.74 | NR4A2 (0.65) | NR4A2CRHR1CD38MAPTL3MBTL1 | |
| SCHEMBL4013824 | 0.73 | NR1H2 (0.56) | — | |
| SCHEMBL28046875 | 0.73 | NR4A2 (0.59) | NR4A2CRHR1MAPTL3MBTL1PARP1 | |
| SCHEMBL4014463 | 0.72 | NR1H2 (0.43) | BDKRB2 | |
| SCHEMBL2449160 | 0.72 | AURKA (0.37) | NR4A2MAPTPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |