Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 5/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28032033 | 0.88 | ACHE (0.44) | TDP1MAPTACHEBCHESMN1; SMN2 | |
| SCHEMBL29286667 | 0.83 | ACHE (0.40) | MAPTACHEBCHESMN1; SMN2LMNA | |
| SCHEMBL27760985 | 0.81 | RAB9A (0.41) | MAPTACHEBCHESMN1; SMN2ALDH1A1 | |
| SCHEMBL27470803 | 0.80 | ACHE (0.43) | MAPTACHEBCHEALDH1A1CASP1 | |
| SCHEMBL29000949 | 0.79 | ACHE (0.42) | TDP1MAPTACHEBCHESMN1; SMN2 | |
| SCHEMBL28043917 | 0.79 | ALDH1A1 (0.51) | TDP1ACHEBCHEALDH1A1LMNA | |
| SCHEMBL5510119 | 0.79 | ELANE (0.55) | TDP1MAPT | |
| SCHEMBL3813706 | 0.78 | MAPT (0.51) | TDP1MAPTACHEBCHESMN1; SMN2 | |
| SCHEMBL4573467 | 0.78 | ACHE (0.41) | ACHEBCHENR1H4 | |
| SCHEMBL2314345 | 0.78 | TSHR (0.48) | TDP1MAPTACHEBCHESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009089042-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2009-07-16 | — | — | WO | disclosed |
| CN-101421262-A | Compounds and compositions as protein kinase inhibitors | IRM LLC (VG) | 2009-04-29 | — | — | CN | disclosed |