Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31039994 | 0.83 | HTR6 (0.44) | HTR6KMT2AMEN1KAT6AGPR17 | |
| SCHEMBL4565530 | 0.80 | KAT6A (0.39) | KMT2AMEN1KAT6AGPR17CA1 | |
| SCHEMBL952515 | 0.79 | KEAP1 (0.45) | KMT2AMEN1LMNAMAPTHTT | |
| SCHEMBL4119819 | 0.78 | TDP1 (0.48) | HTR6KMT2AMAPTSMN1; SMN2CA1 | |
| SCHEMBL22829013 | 0.77 | CA1 (0.38) | HTR6SMN1; SMN2CA1CA2CA9 | |
| SCHEMBL27765108 | 0.77 | CA2 (0.33) | HTR6KAT6ACA1CA2CA9 | |
| SCHEMBL4010898 | 0.76 | CA1 (0.34) | F2HTR6KMT2AMEN1CA1 | |
| SCHEMBL31435685 | 0.76 | KMT2A (0.53) | F2HTR6KMT2AMEN1MAPT | |
| SCHEMBL6113188 | 0.76 | KMT2A (0.53) | F2HTR6KMT2AMEN1MAPT | |
| SCHEMBL4429067 | 0.76 | F2 (0.56) | F2HTR6KMT2AMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |