Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624331 | 0.84 | LOX (0.40) | ACACBNAMPTTDO2HRH3 | |
| SCHEMBL26088700 | 0.76 | PIK3CA (0.39) | PIK3CAPIK3R1HDAC6SYKLRRK2 | |
| SCHEMBL29944695 | 0.76 | DGAT1 (0.44) | PIK3CAPIK3R1HDAC6SYKLRRK2 | |
| SCHEMBL17559331 | 0.76 | FPR2 (0.44) | PIK3CAPIK3R1HDAC6LRRK2SCN9A | |
| SCHEMBL1738661 | 0.76 | DGAT1 (0.44) | PIK3CAPIK3R1HDAC6SYKLRRK2 | |
| SCHEMBL18307136 | 0.76 | FAAH (0.41) | PIK3CAPIK3R1HDAC6SYKLRRK2 | |
| SCHEMBL3396466 | 0.76 | PIK3CA (0.41) | PIK3CAPIK3R1HDAC6SYKLRRK2 | |
| SCHEMBL12310665 | 0.76 | SYK (0.46) | PIK3CAPIK3R1HDAC6SYKLRRK2 | |
| SCHEMBL13662044 | 0.73 | SCN9A (0.44) | PIK3CAPIK3R1ACACBHDAC6SYK | |
| SCHEMBL21108828 | 0.73 | PIK3CA (0.40) | PIK3CAPIK3R1HDAC6SYKLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133970-A1 | CRYSTALLINE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-05 | — | — | WO | disclosed |
| EP-2074117-A2 | HETEROMONOCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008062905-A2 | HETEROMONOCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-29 | — | — | WO | disclosed |