Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOX | P28300 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 7/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.38 |
| ▸ | ACACA | Q13085 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017157 | 0.84 | PIK3CA (0.37) | ACACBHRH3NAMPTTDO2 | |
| SCHEMBL30748869 | 0.75 | LOX (0.46) | LOXLOXL2ACACBPDGFRBPDGFRA | |
| SCHEMBL15147591 | 0.75 | PDGFRB (0.44) | LOXLOXL2ACACBPDGFRBPDGFRA | |
| SCHEMBL1644324 | 0.75 | LOX (0.43) | LOXLOXL2ACACBPDGFRBPDGFRA | |
| SCHEMBL16839481 | 0.75 | FPR2 (0.46) | LOXLOXL2ACACBPDGFRBPDGFRA | |
| SCHEMBL3651197 | 0.75 | LOX (0.46) | LOXLOXL2ACACBPDGFRBPDGFRA | |
| SCHEMBL625001 | 0.75 | DGAT1 (0.46) | LOXLOXL2ACACBPDGFRBPDGFRA | |
| SCHEMBL16839464 | 0.75 | TDO2 (0.44) | LOXLOXL2ACACBPDGFRBPDGFRA | |
| SCHEMBL16924081 | 0.75 | LOX (0.43) | LOXLOXL2ACACBPDGFRBPDGFRA | |
| SCHEMBL16839487 | 0.73 | KDM4E (0.45) | LOXLOXL2ACACBPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603513-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012020848-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-02-16 | — | — | WO | disclosed |