Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR1D | P28221 | 2/20 | 0.42 |
| ▸ | HTR1B | P28222 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.40 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017984 | 0.88 | ALOX5 (0.43) | ALOX5HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL4004501 | 0.85 | HSD11B1 (0.52) | ALOX5HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL2882743 | 0.81 | HTR1A (0.49) | HTR1AHTR1DHTR1BDRD2HTR2A | |
| SCHEMBL4018668 | 0.81 | HTR1A (0.46) | HTR1AHTR1DHTR1BDRD2HTR2A | |
| SCHEMBL8413923 | 0.79 | HTR1A (0.49) | HTR1AHTR1DHTR1BDRD2HTR2A | |
| SCHEMBL7904237 | 0.78 | MGLL (0.50) | ALOX5HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL13853420 | 0.78 | HTR1A (0.46) | HTR1AHTR1DHTR1BDRD2HTR2A | |
| SCHEMBL2883416 | 0.77 | HTR1A (0.45) | HTR1AHTR1DHTR1BDRD2HTR2A | |
| Hydrochloric Acid SCHEMBL4234312 | 0.77 | HTR1A (0.45) | HTR1AHTR1DHTR1BDRD2HTR2A | |
| SCHEMBL19280392 | 0.76 | HSD11B1 (0.50) | ALOX5HTR1AHTR1DHTR1BHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |