Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TKT | P29401 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL479344 | 0.82 | LMNA (0.61) | LMNATKTKDM4EHSP90AA1 | |
| SCHEMBL8445448 | 0.80 | LMNA (0.59) | LMNATKTKDM4EHSP90AA1 | |
| Hydrochloric Acid SCHEMBL6520994 | 0.80 | LMNA (0.59) | LMNATKTKDM4EHSP90AA1 | |
| Phosphoric Acid SCHEMBL851329 | 0.74 | LMNA (0.53) | LMNATKTHSP90AA1 | |
| Phosphoric Acid SCHEMBL1533803 | 0.74 | LMNA (0.53) | LMNATKTHSP90AA1 | |
| Pyrophosphoric Acid SCHEMBL851327 | 0.72 | LMNA (0.51) | LMNATKT | |
| SCHEMBL23748348 | 0.66 | LMNA (0.63) | LMNATKTKDM4EHSP90AA1 | |
| SCHEMBL12346332 | 0.66 | LMNA (0.63) | LMNATKTKDM4E | |
| SCHEMBL29895545 | 0.66 | LMNA (0.63) | LMNATKTKDM4EHSP90AA1 | |
| SCHEMBL478879 | 0.66 | LMNA (0.63) | LMNATKTKDM4EHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009089042-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2009-07-16 | — | — | WO | disclosed |
| WO-2009089042-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2009-07-16 | — | — | WO | disclosed |