Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 8/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2776754 | 0.91 | PNMT (0.42) | PNMTADRA2AADRA2BADRA2CAR | |
| Bicarbonate SCHEMBL8143271 | 0.82 | MAPK1 (0.40) | PNMTADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL4017459 | 0.78 | PNMT (0.42) | PNMTADRA2AADRA2BADRA2CGRIN2B | |
| SCHEMBL2775909 | 0.77 | PNMT (0.33) | PNMTADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL2778779 | 0.76 | PNMT (0.46) | PNMTADRA2AADRA2BADRA2CAR | |
| SCHEMBL4429953 | 0.76 | PNMT (0.52) | PNMTADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL15016457 | 0.74 | CYP19A1 (0.48) | ALDH1A1 | |
| SCHEMBL7456470 | 0.74 | PNMT (0.56) | PNMTADRA2AADRA2BADRA2CAR | |
| SCHEMBL2776959 | 0.73 | ALDH1A1 (0.42) | ALDH1A1GAAGRIN2B | |
| SCHEMBL6195263 | 0.72 | SIRT2 (0.45) | PNMTADRA2AADRA2BADRA2CGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139886-A1 | QUINOLONE AND TETRAHYDROQUINOLINE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | Neuraxon Inc. (CA) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008116308-A1 | QUINOLONE AND TETRAHYDROQUINOLINE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON, INC. (CA) | 2008-10-02 | — | — | WO | disclosed |