Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 6/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 6/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 6/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 6/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 6/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24348363 | 0.81 | PRKAB2 (0.38) | KDM4EUSP2ALDH1A1TSHRPIK3CD | |
| SCHEMBL24349466 | 0.80 | PIK3CB (0.42) | KDM4EPIK3R1PIK3CAMTORPIK3CD | |
| SCHEMBL24348936 | 0.77 | PRKAB2 (0.63) | KDM4EUSP2ALDH1A1TSHRPIK3CD | |
| SCHEMBL10262356 | 0.72 | KDM4E (0.46) | KDM4EUSP2ALDH1A1TSHRPIK3CD | |
| SCHEMBL11034614 | 0.72 | ABL1 (0.42) | PIK3R1PIK3CAMTORKMT2A | |
| SCHEMBL4012820 | 0.71 | IMPDH2 (0.42) | PIK3R1PIK3CAMTOR | |
| SCHEMBL24349472 | 0.70 | PRKAB2 (0.69) | KDM4EUSP2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL17203223 | 0.69 | PIK3CD (0.50) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL14927235 | 0.68 | PIK3CG (0.43) | PIK3R1PIK3CAMTORPIK3CDPIK3CG | |
| SCHEMBL15659764 | 0.68 | ILK (0.43) | KDM4EUSP2ALDH1A1TSHRPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044063-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008001070-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | WO | disclosed |