Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 3/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.38 |
| ▸ | CD38 | P28907 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.37 |
| ▸ | BDKRB2 | P30411 | 2/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4012780 | 0.86 | CD38 (0.41) | ESR1GAAMAPTACVR1CD38 | |
| SCHEMBL4017818 | 0.85 | NR4A2 (0.54) | GAAMAPTNR4A2PDE2APDE10A | |
| SCHEMBL4012142 | 0.83 | ENPP1 (0.44) | GAAMAPTNR4A2PDE2APDE10A | |
| SCHEMBL2451399 | 0.81 | ESR1 (0.42) | ESR1PDE2APDE10ACRHR1TRPV1 | |
| SCHEMBL4009254 | 0.81 | NR1H2 (0.47) | ESR1MAPTCYP3A4 | |
| SCHEMBL4014169 | 0.81 | PIK3CD (0.46) | ESR1GAAMAPTCD38CYP3A4 | |
| SCHEMBL4010841 | 0.78 | RORC (0.40) | ESR1RORCBDKRB2 | |
| SCHEMBL19610603 | 0.78 | MAPT (0.57) | ESR1MAPTNR4A2RORCCRHR1 | |
| SCHEMBL4019153 | 0.77 | NR4A2 (0.50) | GAAMAPTNR4A2CRHR1CD38 | |
| SCHEMBL4010226 | 0.77 | NR1H2 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |