Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 5/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4024254 | 0.78 | CNR2 (0.47) | HTTRAB9AALDH1A1 | |
| SCHEMBL27782461 | 0.77 | MTNR1A (0.47) | MAPTMTNR1AMTNR1BKMT2AMEN1 | |
| SCHEMBL27946328 | 0.76 | KIF11 (0.54) | NR4A2MAPTMTNR1AMTNR1BKMT2A | |
| SCHEMBL31066563 | 0.76 | KMT2A (0.48) | MAPTMTNR1AMTNR1BKMT2AALDH1A1 | |
| SCHEMBL15466939 | 0.74 | ALDH1A1 (0.69) | NR4A2MAPTMTNR1AMTNR1BKMT2A | |
| SCHEMBL28414606 | 0.71 | ALDH1A1 (0.51) | MAPTMTNR1AMTNR1BKMT2AMEN1 | |
| SCHEMBL19924468 | 0.71 | CA12 (0.41) | GPR84MAPTKMT2AMEN1PRKCA | |
| SCHEMBL3968965 | 0.70 | ALDH1A1 (0.54) | MAPTHTTMTNR1AMTNR1BKMT2A | |
| SCHEMBL28411672 | 0.70 | ALDH1A1 (0.54) | MAPTHTTMTNR1AMTNR1BKMT2A | |
| SCHEMBL27859101 | 0.70 | ALDH1A1 (0.40) | MAPTKMT2AMEN1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066318-A2 | OXINDOLE DERIVATIVES AS ANTICANCER AGENTS | F. Hoffmann-Roche AG (CH) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008034736-A2 | OXINDOLE DERIVATIVES AS ANTICANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-27 | — | — | WO | disclosed |