Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | F10 | P00742 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4020602 | 0.78 | NR4A2 (0.50) | RAB9AALDH1A1HTT | |
| SCHEMBL27859101 | 0.69 | ALDH1A1 (0.40) | RAB9AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL26414747 | 0.69 | RAB9A (0.76) | RAB9ANPC1KDM4EALDH1A1HPGD | |
| SCHEMBL25269858 | 0.69 | CNR2 (0.61) | CNR2RAB9ANPC1KDM4EHSD17B10 | |
| SCHEMBL2276515 | 0.68 | CHRNA7 (0.61) | CNR2RAB9ANPC1KDM4EHSD17B10 | |
| SCHEMBL25017939 | 0.67 | SMYD3 (0.43) | CNR2F10KDM4EHSD17B10 | |
| SCHEMBL28585751 | 0.67 | SMYD3 (0.43) | CNR2F10KDM4EHSD17B10 | |
| SCHEMBL19924468 | 0.66 | CA12 (0.41) | KDM4EALDH1A1HPGD | |
| SCHEMBL75198 | 0.65 | MLLT1 (0.65) | CNR2RAB9ANPC1KDM4EHSD17B10 | |
| SCHEMBL19691326 | 0.65 | CNR2 (0.53) | CNR2RAB9AF10NPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066318-A2 | OXINDOLE DERIVATIVES AS ANTICANCER AGENTS | F. Hoffmann-Roche AG (CH) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008034736-A2 | OXINDOLE DERIVATIVES AS ANTICANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-27 | — | — | WO | disclosed |