SCHEMBL40215

SCHEMBL40215

COc1cc(C(F)(F)F)ccc1CN

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 6/20 0.46
MBOAT4 Q96T53 3/20 0.46
HTR2C P28335 2/20 0.46
L3MBTL1 Q9Y468 2/20 0.44
RAB9A P51151 1/20 0.44
IDO1 P14902 2/20 0.44
ANO1 Q5XXA6 1/20 0.42
MAPT P10636 2/20 0.42
GAA P10253 1/20 0.42
TSHR P16473 1/20 0.42
MAPK1 P28482 1/20 0.42
HTT P42858 1/20 0.42
SLC6A4 P31645 3/20 0.41
KCNH2 Q12809 3/20 0.41
NPSR1 Q6W5P4 1/20 0.41
HTR2B P41595 1/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29673193 1.00 HTR2A (0.46) HTR2AMBOAT4HTR2CL3MBTL1RAB9A
SCHEMBL1569552 0.86 HTR2A (0.59) HTR2AHTR2CHTR2B
SCHEMBL40119 0.86 L3MBTL1 (0.47) HTR2AHTR2CL3MBTL1RAB9AIDO1
Hydrochloric Acid SCHEMBL30117084 0.84 L3MBTL1 (0.46) HTR2AHTR2CL3MBTL1RAB9AIDO1
SCHEMBL4623834 0.84 HTR2A (0.45) HTR2AHTR2CMAPTGAATSHR
SCHEMBL10235459 0.84 ANO1 (0.45) HTR2AMBOAT4L3MBTL1RAB9AIDO1
SCHEMBL321002 0.82 ANO1 (0.44) HTR2AMBOAT4HTR2CL3MBTL1RAB9A
SCHEMBL16892265 0.82 MBOAT4 (0.46) HTR2AMBOAT4HTR2CL3MBTL1RAB9A
SCHEMBL31321848 0.82 PDCD1 (0.46) HTR2AMBOAT4L3MBTL1RAB9AIDO1
SCHEMBL6498758 0.82 PDCD1 (0.46) HTR2AMBOAT4L3MBTL1RAB9AIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025224085-A1 COMPOUNDS CAPABLE OF ACTING ON S1R AS WELL AS ON SEH AND USES THEREOF UNIVERSITAT DE BARCELONA (ES) 2025-10-30 WO disclosed
EP-2590656-B1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX INC (US) 2017-11-15 EP disclosed
US-20170037010-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. 2017-02-09 US disclosed
EP-2591354-B1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX INC (US) 2016-09-07 EP disclosed
US-9301951-B2 Compounds and methods for inhibiting phosphate transport ARDELYX, INC. (US) 2016-04-05 US disclosed
US-20150164876-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. 2015-06-18 US disclosed
US-8916569-B2 Compounds and methods for inhibiting phosphate transport ARDELYX, INC. (US) 2014-12-23 US disclosed
US-20140023611-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. 2014-01-23 US disclosed
US-20130336920-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. (US) 2013-12-19 US disclosed
EP-2591354-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT Ardelyx, Inc. (US) 2013-05-15 EP disclosed
EP-2590656-A2 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT Ardelyx, Inc. (US) 2013-05-15 EP disclosed
WO-2012054110-A2 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. (US) 2012-04-26 WO disclosed
WO-2012006475-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. (US) 2012-01-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150164876-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT SLC34A2, SLC34A1, SLC10A2 HTR2A 1684/4885MBOAT4 1993/4885HTR2C 2639/4885
US-20170037010-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT SLC34A2, SLC34A1, SLC10A2 HTR2A 1684/4885MBOAT4 1993/4885HTR2C 2639/4885
US-20140023611-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT SLC10A2, SLC34A2, SLC34A3 HTR2A 3601/4885MBOAT4 1164/4885HTR2C 3694/4885
US-20130336920-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT SLC34A2, SLC34A1, SLC10A2 HTR2A 1684/4885MBOAT4 1993/4885HTR2C 2639/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.