Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 3/20 | 0.56 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.54 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.54 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.54 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3611591 | 0.85 | NOTUM (0.50) | CYP11B2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1422403 | 0.81 | CHRNB2 (0.60) | GABRG2GABRB3GABRA5GABRA3CLK4 | |
| SCHEMBL2539950 | 0.80 | CYP11B2 (0.56) | CYP11B2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL3881340 | 0.80 | CLK4 (0.53) | CYP11B2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL3266198 | 0.80 | CLK4 (0.53) | CYP11B2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL6923115 | 0.80 | CLK4 (0.53) | CYP11B2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL5562910 | 0.80 | MAP4K4 (0.62) | CYP11B2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL18223984 | 0.80 | SYK (0.53) | GABRG2GABRB3GABRA5GABRA3CLK4 | |
| SCHEMBL23228524 | 0.78 | CLK4 (0.59) | GABRG2GABRB3GABRA5GABRA3CLK4 | |
| SCHEMBL29620507 | 0.78 | CLK4 (0.59) | GABRG2GABRB3GABRA5GABRA3CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024152710-A1 | GLUTAMINYL CYCLASE INHIBITOR AND USE THEREOF | 上海市第十人民医院 | 2024-07-25 | — | — | WO | claimed |
| WO-2024152710-A1 | GLUTAMINYL CYCLASE INHIBITOR AND USE THEREOF | 上海市第十人民医院 | 2024-07-25 | — | — | WO | disclosed |
| US-20090203705-A1 | Spiro Compounds As NPY Y5 Receptor Antagonists | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | US | disclosed |
| US-20090203705-A1 | Spiro Compounds As NPY Y5 Receptor Antagonists | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | US | disclosed |
| US-20090203705-A1 | Spiro Compounds As NPY Y5 Receptor Antagonists | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | US | disclosed |
| WO-2009095377-A1 | SPIRO COMPOUNDS AS NPY Y5 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203705-A1 | Spiro Compounds As NPY Y5 Receptor Antagonists | NPY4R, NPY1R, NPY5R | CYP11B2 804/4885GABRG2 372/4885GABRB3 136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.