Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4021783 | 0.80 | CYP11B2 (0.56) | CLK4MAP4K4GABRG2GABRB3GABRA5 | |
| SCHEMBL5562910 | 0.80 | MAP4K4 (0.62) | CLK4MAP4K4GABRG2GABRB3GABRA5 | |
| SCHEMBL3266198 | 0.80 | CLK4 (0.53) | CLK4MAP4K4GABRG2GABRB3GABRA5 | |
| SCHEMBL3881340 | 0.80 | CLK4 (0.53) | CLK4MAP4K4GABRG2GABRB3GABRA5 | |
| SCHEMBL2154026 | 0.78 | CLK4 (0.65) | CLK4MAP4K4GABRG2GABRB3GABRA5 | |
| SCHEMBL18223984 | 0.76 | SYK (0.53) | CLK4MAP4K4GABRG2GABRB3GABRA5 | |
| SCHEMBL5562878 | 0.76 | GABRG2 (0.52) | CLK4MAP4K4GABRG2GABRB3GABRA5 | |
| SCHEMBL5558730 | 0.76 | HSD17B1 (0.60) | CLK4MAP4K4GABRG2GABRB3GABRA5 | |
| SCHEMBL5557633 | 0.76 | CLK4 (0.54) | CLK4MAP4K4GABRG2GABRB3GABRA5 | |
| SCHEMBL14224867 | 0.76 | CLK4 (0.49) | CLK4MAP4K4GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441719-A1 | N-SUBSTITUTED PYRROLIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003037327-A1 | N-SUBSTITUTED PYRROLIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | F. HOFFMANN-LA-ROCHE AG (CH) | 2003-05-08 | — | — | WO | disclosed |