Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 0.56 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.45 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24365782 | 0.85 | RIPK1 (0.63) | RIPK1TMEM97SIGMAR1HSD11B1PRMT5 | |
| SCHEMBL7469150 | 0.85 | RIPK1 (0.63) | RIPK1TMEM97SIGMAR1HSD11B1PRMT5 | |
| SCHEMBL17114341 | 0.85 | RIPK1 (0.63) | RIPK1TMEM97SIGMAR1HSD11B1PRMT5 | |
| Water SCHEMBL27902502 | 0.84 | RIPK1 (0.62) | RIPK1TMEM97SIGMAR1HSD11B1PRMT5 | |
| SCHEMBL30281143 | 0.84 | RIPK1 (0.62) | RIPK1TMEM97SIGMAR1HSD11B1PRMT5 | |
| SCHEMBL27830000 | 0.82 | RIPK1 (0.59) | RIPK1TMEM97SIGMAR1HSD11B1PRMT5 | |
| SCHEMBL6960066 | 0.81 | RIPK1 (0.69) | RIPK1EPHX2HSP90AA1HSP90AB1 | |
| SCHEMBL18642714 | 0.81 | RIPK1 (0.69) | RIPK1EPHX2HSP90AA1HSP90AB1 | |
| SCHEMBL8303313 | 0.80 | TMEM97 (0.58) | RIPK1TMEM97SIGMAR1HSD11B1PRMT5 | |
| SCHEMBL4277144 | 0.80 | RIPK1 (0.59) | RIPK1TMEM97SIGMAR1HSD11B1PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545525-A4 | RADIOLABELED NEUROKININ-1 RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1119356-A4 | RADIOLABELED NEUROKININ-1 RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1545525-A2 | RADIOLABELED NEUROKININ-1 RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004029024-A2 | RADIOLABELED NEUROKININ-1 RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2004-04-08 | — | — | WO | disclosed |
| EP-1119356-A1 | RADIOLABELED NEUROKININ-1 RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000018403-A1 | RADIOLABELED NEUROKININ-1 RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-04-06 | — | — | WO | disclosed |