Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.53 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.45 |
| ▸ | CTSA | P10619 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | PRKX | P51817 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23100732 | 0.88 | ROCK1 (0.53) | ROCK1ROCK2CNR2HDAC4HDAC7 | |
| SCHEMBL3585946 | 0.88 | ROCK1 (0.53) | ROCK1ROCK2CNR2HDAC4HDAC7 | |
| SCHEMBL4019303 | 0.87 | ROCK1 (0.52) | ROCK1ROCK2CDC42BPACNR2HDAC4 | |
| SCHEMBL14691111 | 0.83 | PHGDH (0.50) | ROCK1ROCK2CTSAPRKACACDK8 | |
| SCHEMBL5674456 | 0.83 | ROCK2 (0.50) | ROCK1ROCK2CNR2HDAC4HDAC7 | |
| SCHEMBL3886204 | 0.82 | ROCK1 (0.56) | ROCK1ROCK2PRKACACDK8GSK3A | |
| SCHEMBL1120036 | 0.82 | ROCK1 (0.56) | ROCK1ROCK2PRKACACDK8GSK3A | |
| SCHEMBL22690989 | 0.82 | ALDH1A1 (0.43) | ROCK1ROCK2CDC42BPACYP26A1CTSA | |
| SCHEMBL16396919 | 0.82 | ALDH1A1 (0.43) | ROCK1ROCK2CDC42BPACYP26A1CTSA | |
| SCHEMBL3447133 | 0.81 | MAPT (0.46) | CTSASLC6A9CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579471-B2 | Tropane derivatives useful in therapy | PFIZER, INC. (US) | 2009-08-25 | — | — | US | disclosed |
| US-20070185157-A1 | Tropane derivatives useful in therapy | AGOURON PHARMACEUTICALS, INC. | 2007-08-09 | — | — | US | disclosed |
| US-7217721-B2 | Tropane derivatives useful in therapy | PFIZER, INC. (US) | 2007-05-15 | — | — | US | disclosed |
| EP-1492789-B1 | TROPANE DERIVATIVES AS CCR5 MODULATORS | PFIZER LTD (GB) | 2006-06-07 | — | — | EP | disclosed |
| US-20050107424-A1 | Tropane derivatives useful in therapy | AGOURON PHARMACEUTICALS, INC. | 2005-05-19 | — | — | US | disclosed |
| US-6855724-B2 | Tropane derivatives useful in therapy | AGOURON PHARMACEUTICALS, INC. (US) | 2005-02-15 | — | — | US | disclosed |
| EP-1492789-A1 | TROPANE DERIVATIVES AS CCR5 MODULATORS | Pfizer Limited (GB) | 2005-01-05 | — | — | EP | disclosed |
| US-20040014742-A1 | Antiinflammatory agents; viricides | PFIZER INC. | 2004-01-22 | — | — | US | disclosed |
| WO-2003084954-A1 | TROPANE DERIVATIVES AS CCR5 MODULATORS | PFIZER LIMITED (GB) | 2003-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014742-A1 | Antiinflammatory agents; viricides | CCR5, CXCR1, CCR1 | ROCK1 466/4885ROCK2 1134/4885CDC42BPA 1778/4885 |
| US-20050107424-A1 | Tropane derivatives useful in therapy | CCR5, CXCR4, CX3CR1 | ROCK1 1402/4885ROCK2 1696/4885CDC42BPA 1234/4885 |
| US-20070185157-A1 | Tropane derivatives useful in therapy | CCR5, CXCR4, CX3CR1 | ROCK1 1402/4885ROCK2 1696/4885CDC42BPA 1234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.