Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | CPT2 | P23786 | 1/20 | 0.43 |
| ▸ | CPT1A | P50416 | 1/20 | 0.43 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | KLK1 | P06870 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5245114 | 0.87 | HDAC1 (0.53) | HDAC1HDAC8HDAC6LMNAHSD17B10 | |
| SCHEMBL3451193 | 0.81 | HDAC1 (0.52) | HDAC1HDAC8HDAC6KDM4EALDH1A1 | |
| SCHEMBL19327449 | 0.79 | LMNA (0.54) | LMNAHSD17B10GABRA5GABRB2EGLN1 | |
| SCHEMBL5382825 | 0.78 | HDAC1 (0.49) | HDAC1HDAC8HDAC6LMNAKDM4E | |
| SCHEMBL1999671 | 0.77 | HDAC1 (0.71) | HDAC1HDAC8HDAC6KDM4EALDH1A1 | |
| SCHEMBL4820977 | 0.76 | HDAC1 (0.43) | HDAC1HDAC8HDAC6LMNAHSD17B10 | |
| SCHEMBL4820969 | 0.76 | HDAC1 (0.43) | HDAC1HDAC8HDAC6LMNAHSD17B10 | |
| SCHEMBL4817388 | 0.76 | HDAC1 (0.43) | HDAC1HDAC8HDAC6HSD17B10EGLN1 | |
| SCHEMBL11392035 | 0.75 | KDM4E (0.63) | HDAC6LMNAKDM4EALDH1A1HPGD | |
| SCHEMBL5461325 | 0.75 | LMNA (0.72) | LMNAHSD17B10GABRA5GABRB2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109456324-B | Isoindoline or isoquinoline compounds, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2022-04-22 | — | — | CN | disclosed |
| US-11028070-B2 | Isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2021-06-08 | — | — | US | disclosed |
| US-20200262816-A1 | ISOINDOLINE OR ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2020-08-20 | — | — | US | disclosed |
| US-10689364-B2 | Isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2020-06-23 | — | — | US | disclosed |
| EP-3024826-B1 | NEW ISOINDOLINE OR ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2018-11-14 | — | — | EP | disclosed |
| US-20180002313-A1 | ISOINDOLINE OR ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2018-01-04 | — | — | US | disclosed |
| US-9809574-B2 | Isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2017-11-07 | — | — | US | disclosed |
| US-20160194304-A1 | ISOINDOLINE OR ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2016-07-07 | — | — | US | disclosed |
| EP-3024826-A1 | NEW ISOINDOLINE OR ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Les Laboratoires Servier (FR) | 2016-06-01 | — | — | EP | disclosed |
| WO-2015011164-A1 | NEW ISOINDOLINE OR ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2015-01-29 | — | — | WO | disclosed |
| WO-2003086385-A1 | DERIVATIVES OF 1-(OXOAMINOACETYL) PENTYLCARBAMATE AS CATHEPSIN K INHIBITORS FOR THE TREATMENT OF BONE LOSS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-10-23 | — | — | WO | disclosed |
| US-20030199532-A1 | 2,4-substituted pyrrolidine derivatives-CCR-3 receptor antagonists | KERTESZ DENIS JOHN (US) | 2003-10-23 | — | — | US | disclosed |
| EP-1324990-A1 | MORPHOLIN-ACETAMIDE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2003-07-09 | — | — | EP | disclosed |
| US-6552028-B2 | Inhibiting the binding of eotaxin to chemokine-3 (ccr-3) receptor; antiasthmatics | SYNTEX (U.S.A.) LLC | 2003-04-22 | — | — | US | disclosed |
| US-20020198255-A1 | 2,4-substituted pyrrolidine derivatives-CCR-3 receptor antagonists | SYNTEX (U.S.A.) LLC | 2002-12-26 | — | — | US | disclosed |
| WO-2002050064-A1 | SUBSTITUTED PYRROLIDINES AS CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-27 | — | — | WO | disclosed |
| WO-2002026722-A1 | MORPHOLIN-ACETAMIDE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2002-04-04 | — | — | WO | disclosed |
| EP-1131288-A1 | PYRROLIDINE DERIVATIVES-CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-09-12 | — | — | EP | disclosed |
| US-6166015-A | Pyrrolidine derivatives-CCR-3 receptor antagonists | SYNTEX (U.S.A.) INC. (US) | 2000-12-26 | — | — | US | disclosed |
| WO-2000031032-A1 | PYRROLIDINE DERIVATIVES-CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180002313-A1 | ISOINDOLINE OR ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BAX, CASP7, CASP3 | HDAC1 2046/4885HDAC8 3516/4885HDAC6 1623/4885 |
| US-20200262816-A1 | ISOINDOLINE OR ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BAX, RECQL, CASP7 | HDAC1 2191/4885HDAC8 3615/4885HDAC6 1755/4885 |
| US-20160194304-A1 | ISOINDOLINE OR ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RECQL, UQCRB, IRF3 | HDAC1 2837/4885HDAC8 3888/4885HDAC6 2509/4885 |
| US-10689364-B2 | Isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them | BAX, CASP7, CASP3 | HDAC1 2046/4885HDAC8 3516/4885HDAC6 1623/4885 |
| US-20030199532-A1 | 2,4-substituted pyrrolidine derivatives-CCR-3 receptor antagonists | CCR3, CCR1, CCR4 | HDAC1 1188/4885HDAC8 1661/4885HDAC6 528/4885 |
| US-11028070-B2 | Isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them | BAX, RECQL, CASP7 | HDAC1 2191/4885HDAC8 3615/4885HDAC6 1755/4885 |
| US-20020198255-A1 | 2,4-substituted pyrrolidine derivatives-CCR-3 receptor antagonists | CCR3, CCR1, CCR4 | HDAC1 1188/4885HDAC8 1661/4885HDAC6 528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.