Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL358305 | 0.93 | PKM (0.54) | LMNAPKMMAPTALDH1A1TSHR | |
| SCHEMBL1784674 | 0.87 | LMNA (0.53) | LMNAPKMMAPTALDH1A1TSHR | |
| SCHEMBL29739541 | 0.87 | ALDH1A1 (0.49) | LMNAMAPTALDH1A1TSHRRAB9A | |
| SCHEMBL359390 | 0.87 | ALDH1A1 (0.49) | LMNAMAPTALDH1A1TSHRRAB9A | |
| Hydrochloric Acid SCHEMBL11778515 | 0.86 | LMNA (0.52) | LMNAPKMMAPTALDH1A1TSHR | |
| SCHEMBL30180164 | 0.83 | PKM (0.55) | LMNAPKMMAPTALDH1A1TSHR | |
| SCHEMBL10341213 | 0.83 | PKM (0.55) | LMNAPKMMAPTALDH1A1TSHR | |
| SCHEMBL14993397 | 0.83 | PKM (0.51) | LMNAPKMMAPTALDH1A1TSHR | |
| SCHEMBL8526398 | 0.81 | TSHR (0.53) | LMNAMAPTALDH1A1TSHRRAB9A | |
| SCHEMBL3122999 | 0.81 | RAB9A (0.50) | LMNAMAPTALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046793-A2 | FUSED PYRIMIDO COMPOUNDS | AstraZeneca AB (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008003958-A2 | FUSED PYRIMIDO COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |